clarithromycin 500 dosage priligy

(see section 4.5).As with other strong CYP3A4 inhibitors, Clarithromycin should not be used in patients taking colchicine (see sections 4.4 and 4.5).Clarithromycin should not be given to patients with hypokalaemia (risk of prolongation of QT-time).Clarithromycin should not be used in patients who suffer from severe hepatic failure in combination with renal impairment.Use of any antimicrobial therapy, such as clarithromycin, to treat The physician should not prescribe clarithromycin to pregnant women without carefully weighing the benefits against risk, particularly during the first three months of pregnancy (see section 4.6).Caution is advised in patients with severe renal insufficiency (see section 4.2).Clarithromycin is principally metabolised by the liver. Acute generalised exanthematous pustulosis (AGEP), Stevens-Johnson Syndrome, toxic epidermal necrolysis and drug rash with eosinophilia and systemic symptoms (DRESS)) clarithromycin therapy should be discontinued immediately and appropriate treatment should be urgently initiated.Clarithromycin should be used with caution when administered concurrently with medications that induce the cytochrome CYP3A4 enzyme (see section 4.5).Rhabdomyolysis has been reported in patients taking clarithromycin and statins. Reduction of sildenafil, tadalafil and vardenafil dosages should be considered when these drugs are co-administered with clarithromycin.Results of clinical studies indicate that there was a modest but statistically significant (p≤ 0.05) increase of circulating theophylline or carbamazepine levels when either of these drugs were administered concomitantly with clarithromycin. “IE" indicates that there is insufficient evidence that the species in question is a good target for therapy with the drug.Clarithromycin has been used in small numbers of patients in other treatment regimens. This may result in QT prolongation and cardiac arrhythmias including ventricular tachycardia, ventricular fibrillation and torsades de pointes. Slight reductions in erythrocytes, platelets and leukocytes have also been found in juvenile animals.Clarithromycin has not been tested for carcinogenicity.This medicinal product does not require any special storage conditions.Clarithromycin 500 mg tablets are available in clear PVC /PVdC/Aluminium blister packs of: 7, 12, 14 and 21 film-coated tablets.Any unused medicinal product or waste material should be disposed of in accordance with local requirements.Odyssey Business Park, Ares Block, West End Road, South Ruislip, Middlesex, HA4 6QDTo bookmark a medicine you must sign up and log in.To view the changes to a medicine you must sign up and log in. • Skin infections and soft tissue infections of mild to moderate severity, This information is intended for use by health professionalsEach film-coated tablet contains 500 mg of clarithromycinLight yellow coloured, oval shaped, biconvex film-coated tablets, with 'D' debossed on one side and '63' on the other side. Because clarithromycin appears to interfere with the absorption of simultaneously administered oral zidovudine, this interaction can be largely avoided by staggering the doses of clarithromycin and zidovudine to allow for a 4-hour interval between each medication. Concomitant administration of rifabutin and clarithromycin resulted in an increase in rifabutin, and decrease in clarithromycin serum levels together with an increased risk of uveitis.The following drugs are known or suspected to affect circulating concentrations of clarithromycin; clarithromycin dosage adjustment or consideration of alternative treatments may be required.Strong inducers of the cytochrome P450 metabolism system such as efavirenz, nevirapine, rifampicin, rifabutin, and rifapentine may accelerate the metabolism of clarithromycin and thus lower the plasma levels of clarithromycin, while increasing those of 14-OH-clarithromycin, a metabolite that is also microbiologically active. For patients with creatinine clearance <30 mL/min, the dose of clarithromycin should be decreased by 75% using an appropriate clarithromycin formulation. • Concomitant administration of clarithromycin with astemizole, cisapride, pimozide and terfendine is contraindicated (see section 4.3). Child dosage (ages 6 months–17 years) The recommended dosage is 7.5 mg/kg every 12 hours, up to 500 mg …

Acute generalised exanthematous pustulosis (AGEP), Stevens-Johnson Syndrome, and toxic epidermal necrolysis, clarithromycin therapy should be discontinued immediately and appropriate treatment should be urgently initiated.Clarithromycin should be used with caution when administered concurrently with medications that induce the cytochrome CYP3A4 enzyme (see section 4.5).Use of any antimicrobial therapy, such as clarithromycin, to treat H. pylori infection may select for drug-resistant organisms. Observations from drug interaction studies using the soft gelatin capsule formulation may not be representative of the effects seen using the saquinavir hard gelatin capsule. For patients with moderate renal function (creatinine clearance 30 to 60 mL/min), the dose of clarithromycin should be decreased by 50%. An exception is Haemophilus influenza where the 14-hydroxy metabolite is two-fold more active than the parent compound.Clarithromycin is usually active against the following organisms in vitro:-Clarithromycin has bactericidal activity against several bacterial strains.

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