difference between ace inhibitors and diuretics coversyl

Stopping the diuretic or increasing salt intake prior to taking the ACE inhibitor may prevent excessive blood pressure reduction. In almost every case the confidence intervals in ANBP2 substantially overlapped the estimates of effect identified in ALLHAT.Overall, the findings of ALLHAT and ANBP2 are probably not as divergent as they might at first seem.

The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)ALLHAT was a very large, North American trial in which around 42 000 people with hypertension were randomised to take either an ACE inhibitor, a diuretic, a calcium antagonist or an alpha adrenergic blocker. In terms of the secondary outcomes, there was a 32% (1-53%) greater reduction in the risk of non-fatal myocardial infarction with ACE inhibitor therapy compared to diuretic therapy. ANBP2 has not yet reported findings … Overall therefore, ACE inhibitors seemed to be superior to diuretics, however, for both primary and secondary outcomes, differences between treatment groups in cause-specific fatal and nonfatal events were only seen in men.The risk of developing type 2 diabetes in the ALLHAT trial was 40% higher with diuretic therapy than with ACE inhibitor therapy. Coversyl: Perindopril belongs to the class of medications called angiotensin converting enzyme (ACE) inhibitors. Health professionals also need to stay up to date with the latest evidence as it emerges.



However, for the secondary outcomes, the risks of stroke (15% lower relative risk, 95% CIThe ANBP2 trial reported an 11% (0-21%) reduction in the risk of its primary outcome (any cardiovascular event or death from any cause) in favour of the ACE inhibitor group compared to the diuretic group.

For example, the usual starting dose of benazepril, a common ACE inhibitor, is 10 mg daily.

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