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Overall, approximately 0.5% of all subjects treated with CIALIS for on demand use discontinued treatment as a consequence of back pain/myalgia. The safety and efficacy of combinations of CIALIS and other PDE5 inhibitors or treatments for erectile dysfunction have not been studied. Amlodipine a prescription medication that is used with or without other medications to treat high blood pressure.Lowering blood pressure helps prevent strokes, heart attacks, and kidney problems. The following adverse reactions were reported (Additional, less frequent adverse reactions (<1%) reported in the controlled clinical trials of CIALIS for BPH or ED and BPH included: gastroesophageal reflux disease, upper abdominal pain, nausea, vomiting, arthralgia, and muscle spasm.

Insufficient data are available for subjects with severe hepatic impairment (Child-Pugh Class C). This medicine is available only with your doctor's prescription. These highlights do not include all the information needed to use CIALIS safely and effectively. Table 2: Treatment-Emergent Adverse Reactions Reported by ≥2% of Patients Treated with CIALIS for Once Daily Use (2.5 or 5 mg) and More Frequent on Drug than Placebo in the Three Primary Placebo-Controlled Phase 3 Studies of 12 weeks Treatment Duration (Including a Study in Patients with Diabetes) for CIALIS for Once Daily Use for ED

CIALIS is available as almond-shaped tablets for oral administration. No severe adverse events potentially related to blood-pressure effects were reported.

June 12, 2020 In tadalafil clinical pharmacology trials, back pain or myalgia generally occurred 12 to 24 hours after dosing and typically resolved within 48 hours.

No severe adverse events potentially related to blood pressure effects were reported.

In most patients, the ability to have sexual intercourse is improved for up to 36 hours. Efficacy Results in ED Patients with Diabetes MellitusTable 18: Mean Endpoint and Change from Baseline for the Primary Efficacy Variables in a CIALIS for Once Daily Use Study in ED Patients with Diabetes The penis is one of the areas where this enzyme works. The IPSS assesses the severity of irritative (frequency, urgency, nocturia) and obstructive symptoms (incomplete emptying, stopping and starting, weak stream, and pushing or straining), with scores ranging from 0 to 35; higher numeric scores representing greater severity. In animal reproduction studies, no adverse developmental effects were observed with oral administration of tadalafil to pregnant rats or mice during organogenesis at exposures up to 11 times the maximum recommended human dose (MRHD) of 20 mg/day (Animal reproduction studies showed no evidence of teratogenicity, embryotoxicity, or fetotoxicity when tadalafil was given orally to pregnant rats or mice at exposures up to 11 times the maximum recommended human dose (MRHD) of 20 mg/day during organogenesis.

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Placebo-subtracted mean maximal decrease in systolic blood pressure (mm Hg)Table 6: Doxazosin (8 mg/day) Study 2 (Part C): Mean Maximal Decrease in Systolic Blood Pressure

Concomitant use of nitrates in any form is contraindicated Four strengths of almond-shaped tablets are available in different sizes and different shades of yellow:

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